Professeur de Neurosciences

Enseignements en cours:

  • Informatique pour les Neurosciences (licence)
  • Statistiques appliquées aux sciences de la vie (licence, master, PhD)
  • Modélisation du neurone et des systèmes neuronaux (licence, master, PhD)
  • Introduction aux modèles des sciences cognitives (master)

Thématiques de recherche:

  • Caractérisation des dynamiques spatio-temporelles des systèmes neuronaux et comportementaux. Approches dynamiques, statistiques et multi-échelles.
  • Méthodes statistiques d’analyse des données

Principales publications:

1. Nandrino J.-L., Pezard L., Martinerie J., El Massioui F., Renault B., Jouvent R., Allilaire J.-F. & Widlocher D. Decrease of complexity in EEG as a symptom of depression. NeuroReport, 1994, 5, 528–530.

2. Pezard L., Martinerie J., Breton F., Bourzeix J.-C. & Renault B. Nonlinear forecasting measurements of multichannel EEG dynamics. Electroencephalography and Clinical Neurophysiology, 1994, 91, 383–391.

3. Pezard L. & Nandrino J.-L. Dynamique cérébrale et pathologie mentale: vers une approche dynamique de la dépression. Revue Internationale de Psychopathologie, 1994, 15, 443–458.

4. Pezard L., Nandrino J.-L., Renault B , El Massioui F., Allilaire J.-F., Müller J., Varela F.J. & Martinerie J. Depression as a dynamical disease. Biological Psychiatry, 1996, 39, 991–999.

5. Müller J., Neuenschwander S., Martinerie J., Pezard L., Renault B. & Varela F.J. Detecting non-linearities in neuro-electrical signals: a study of synchronous local field potentials. Physica D. 1996, 94, 65–91.

6. Pezard L., Martinerie J., Müller J., Varela F.J. & Renault B. Entropy quantification of human brain spatio-temporal dynamics. Physica D. 1996, 96, 344–354.

7. Pezard L., Lachaux J.-Ph., Nandrino J.-L., Adam C., Garnero L., Renault B., Varela F. J. & Martinerie J. Local and global entropy quantification in neuronal systems. Journal of Technical Physics. 1997, 38, 319–322.

8. Lachaux J.-Ph., Pezard L., Garnero L., Pelte C., Renault B., Varela F.J. & Martinerie J. The spatial extension of brain activity fools the single-channel reconstruction of EEG dynamics. Human Brain Mapping. 1997, 5, 26–47.

9. Gagey P.M., Martinerie J., Pezard L. & Benaim C. Le système postural fin fonctionne comme un système dynamique non-linéaire. Annales d’Otolaryngologie et de Chirurgie Cervicofaciale. 1998, 115, 161–168.

10. Pezard L., Martinerie J., Varela F.J., Bouchet F., Derouesné C. & Renault B. Brain entropy maps quantify drug dosage on Alzheimer’s disease. Neuroscience Letters. 1998, 253, 5–8.

11. Pezard L., Lachaux J.-Ph., Thomasson N. & Martinerie J. Why bother to spatially embed EEG? Comments on Pritchard et al., Psychophysiology , 33, 362–368, 1996. Psychophysiology. 1999, 36, 527–531.

12. Thomasson N. & Pezard L. Dynamical system and depression: A framework for theoretical perspectives. Acta Biotheoretica. 1999, 47, 3-4, 209–218.

13. Thomasson N., Pezard L. , Allilaire J.-F., Renault B. & Martinerie J. Nonlinear EEG changes associated with clinical improvement in depressed patients. Nonlinear Dynamics in Psychology and Life Sciences. 2000, 4, 3, 203–218.

14. Thomasson N., Pezard L. & Renault B. Rémission d’épisodes dépressifs et réorganisation au sein de la dynamique cérébrale. In Cognito — Cahiers Romans de Sciences Cognitives, 2000 n°18, 35–41.

15. Pezard L. & Nandrino J.-L. Paradigme dynamique en psychopathologie. La théorie du chaos, de la physique à la psychiatrie. L’Encéphale. 2001, XXVII, 260–268.

16. Pezard L., Jech R. & Růžička E. Investigation of non-linear properties of multichannel EEG in early stage of Parkinson’s disease. Clinical Neurophysiology. 2001, 112, 1, 38–45.

17. Thomasson N., Pezard L., Renault B. & Martinerie J. Nonlinear EEG Changes in a 48-hour Cyclic Manic-Depressive Patient. Nonlinear Dynamics in Psychology and Life Sciences. 2002, 6, 3, 259–267.

18. Nandrino J.-L., Pezard L., Posté A., Réveillère C. & Beaune D. Autobiographical memory in major depression: A comparison between first episode and recurrent patients. Psychopathology. 2002, 35, 335–340.

19. Nandrino J.-L., Leroy F. & Pezard L. Dynamics as a heuristic framework for psychopathology Chaos and Complexity Letters. 2005, 1, 145–177.

20. Leroy F., Pezard L. , Nandrino, J.-L. & Beaune D. Dynamical quantification of schizophrenic speech. Psychiatry Research 2005, 133, 159–171.

21. Degos B., Deniau, J.-M., Thierry A.-M., Glowinski J., Pezard L. & Maurice N. Neuroleptic-induced catalepsy: electrophysiological mechanisms of functional recovery induced by high-frequency stimulation of the subthalamus nucleus. The Journal of Neuroscience 2005, 25, 7687–7696.

22. Nandrino J.-L., Doba K., Christophe V., Lesne A. & Pezard L. Autobiographical memory deficit in anorexia nervosa: emotion regulation and effect of illness duration. Journal of Psychosomatic Research 2006, 61, 4, 537–543.

23. Carvunis A.-R., Latapy M., Lesne A., Magnien C. & Pezard L. Dynamics of three-state excitable units on Poisson vs. power-law random networks. Physica A 2006, 367, 595–612.

24. Mahon S., Vautrelle N., Pezard L., Slaght S., Deniau J.-M., Chouvet G. & Charpier S. Distinct patterns of striatal medium spiny neuron activity during the natural sleep-wake cycle, The Journal of Neuroscience 2006, 26, 12587–12595.

25. Doba K., Pezard L., Lesne A., Vignau J., Christophe V. & Nandrino J.L. Dynamics of emotional expression in autobiographic speech of patients with anorexia nervosa. Psychological Reports 2007, 101, 237–249.

26. Doba K., Nandrino J.-L., Lesne A., Vignau J. & Pezard L. Organization of the narrative components in autobiographic speech of anorexic patients: A statistical and non-linear dynamical analysis. New Ideas in Psychology 2008, 26, 293–308.

27. Pezard L. & Lesne A. Cellular automata approach of transmembrane ionic currents. Journal of Integrative Neurosciences 2008, 7, 271–286.

28. Robin K., Maurice N., Degos B. J.-M. Deniau, Marinerie J. & Pezard L. Assessment of bursting activity and interspike intervals variability: A case study for methodological comparison. Journal of Neurosciences Methods 2009, 179, 142-149.

29. Lesne A., Blanc J.-L. & Pezard L. Entropy estimation of very short symbolic sequences. Physical Review E 2009, 79, 046208.

30. Norena A.J., Moffat G., Blanc J.L., Pezard L. & Casals Y. Neural changes in the auditory cortex of awake guinea pigs after two tinnitus inducers: salicylate and acoustic trauma. Neuroscience 2010, 166, 1194-1209.

31. Blanc J.-L., Pezard L. & Lesne A. Delay independence of mutual-information rate of two symbolic sequences. Physical Review E 2011, 84, 036214.

32. Lenne B., Blanc J.L., Nandrino J.-L., Gallois P., Hautecoeur P., & Pezard L. Decrease of interhemispheric mutual information in
multiple sclerosis. Behavioral Neurology 2013; 27(2):201-12. doi: 10.3233/BEN-120278.

33. Hadriche A, Pezard L, Nandrino JL, Ghariani H, Kachouri A, Jirsa VK. Mapping the dynamic repertoire of the resting brain. Neuroimage. 2013 Sep;78:448-62. doi: 10.1016/j.neuroimage.2013.04.041. Epub 2013 Apr 23.

34. Abir Hadriche, Nawel Jmail, Hamadi Ghariani, Abdennaceur Kachouri and Laurent Pezard. Article: Reduction of Continuous Neuronal Model to Discrete Binary Automata. International Journal of Computer Applications 69(24):5-10, May 2013.

35. Doba K, Pezard L, Berna G, Vignau J, Nandrino JL. Affiliative behaviour and conflictual communication during brief family therapy of patients with anorexia nervosa. PLoS One. 2013 Aug 1;8(8):e70389. doi: 10.1371/journal.pone.0070389. Print 2013.

36. Woodman M., Pezard L., Domide L., Knock S.A., Sanz-Leon P., Mersmann J., McIntosh A.R and Jirsa V.K., Integrating neuroinformatics tools in TheVirtualBrain Front. Neuroinform., 22 April 2014 | doi: 10.3389/fninf.2014.00036

37. Aidi-Knani S, Pezard L, Mpari B, Ben Hamida J, Sabatier JM, Mourre C, Regaya I. Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system. Eur J Pharmacol. 2015 Apr 5;752:106-11. doi: 10.1016/j.ejphar.2015.02.011.