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Nom, prénom: Xerri Christian

Statut : DR1 CNRS

Fonction : Directeur d’unité (UMR 7260-AMU/CNRS)

Email: christian.xerri@univ-amu.fr

Téléphone : 04 13 55 09 55









Parcours de recherche :

1979-1981 : Thèse de doctorat de 3ème cycle (Istituto di Fisiologia Umana ; Pr O. Pompeiano ; Université de Pise, Italie).

1982 : Chargé de recherche au CNRS.

1989 : Thèse d’Etat es Sciences Naturelles (Laboratoire de Neurobiologie Intégrative et Adaptative ; Pr M. Hugon ; Université de Provence, Marseille).

1990-1992: Assistant Professor (Keck Center for Integrative Neuroscience; Pr M. M. Merzenich; University of California at San Francisco, USA).

1991: Directeur de recherche au CNRS.

2008-2011: Directeur de l’UMR 6149, Neurosciences Intégratives et Adaptatives, Université de Provence/CNRS, Marseille.

2012-2017: Directeur de l’UMR 7260, Neurosciences Intégratives et Adaptatives, Aix-Marseille Université/CNRS.


Thèmes de recherche

  • Développement et maturation des cartes du cortex somesthésique.
  • Remodelage postlésionnel des cartes somesthésiques chez l’animal cérébrolésé.
  • Mécanismes biochimiques et morphologiques impliqués dans la neuroplasticité des cartes somesthésiques.
  • Thérapie cellulaire, rééducation fonctionnelle et malléabilité des cartes corticales après lésion de la moelle épinière.
  • Codage spatio-temporel des stimulations tactiles au sein des réseaux corticaux et illusions perceptives.

Bibliographie (sélection d’articles)


  1. THOMATY S, PEZARD L, XERRI C, BREZUN J-M (2017) Acute granulocyte macrophage-colony stimulating factor treatment modulates neuroinflammatory processes and promotes tactile recovery after spinal cord injury. Neuroscience, 349: 144-164.
  2. ZENNOU-AZOGUI Y, XERRI C (2016) Hypergravity experience within a critical period impacts on the maturation of somatosensory cortical maps and their potential for use-dependent plasticity in the adult. Neurophysiol, 115: 2740–2760; doi:10.1152/jn.00900.2015).
  3. XERRI C, ZENNOU-AZOGUI Y, SADLAOUD K, SAUVAJON D (2014) Interplay between intra- and interhemispheric remodeling of neural networks as a substrate of functional recovery after stroke: adaptive versus maladaptive reorganization. Neuroscience 1016/j.neuroscience.2014.06.066.
  4. XERRI C, ZENNOU-AZOGUI Y, (2014) Early and moderate sensory stimulation exerts a protective effect on perilesion representations of somatosensory cortex after focal ischemic damage. Plos One. 9:7 e99767 (14 pages).
  5. XERRI C (2012) Plasticity of cortical maps: multiple triggers for adaptive reorganization following brain damage and spinal cord injury. The Neuroscientist. 18: 133-148.
  6. MARTINEZ M, BREZUN JM, XERRI C (2011) Sensorimotor experience influences recovery of forelimb abilities but not tissue loss after focal cortical compression in adult rats. Plos One. 6(2): e16726 (11 pages).
  7. MARTINEZ M, DELCOUR M, RUSSIER M, ZENNOU-AZOGUI Y, BREZUN JM, XERRI C, COQ JO (2010) Differential tactile and motor recovery and cortical map alteration after C4-C5 spinal hemisection. Exp. Neurol. 221: 186-197.
  8. MARTINEZ M, BREZUN JM, ZENNOU-AZOGUI Y, BARIL N, XERRI C (2009) Sensorimotor training promotes functional recovery and somatosensory cortical map reactivation following cervical spinal cord injury. E. J. Neurosci. 30: 2356-2367.
  9. MARTINEZ M, BREZUN JM, BONNIER L, XERRI C (2009) A new rating scale for open-field evaluation of behavioral recovery after cervical spinal cord injury in rats. J. Neurotrauma. 26, 1043-1053.
  10. XERRI C (2008) Imprinting of idyosyncratic experience in cortical sensory maps: Neural substrates of representational remodeling and correlative perceptual changes. Behav. Brain Res. 192: 26-41.
  11. ROSSELET C, ZENNOU-AZOGUI Y, ESCOFFIER G, KIRMACI F, XERRI C (2008) Experience-dependent changes in spatiotemporal properties of cutaneous inputs remodel somatosensory cortical maps following skin flap rotation. E. J. Neurosci. 27:1245-1260.
  12. MIQUEE A, XERRI C, RAINVILLE C, ANTON JL, NAZARIAN B, ROTH M, ZENNOU-AZOGUI Y (2008) Neuronal substrates of haptic shape encoding and matching: A functional magnetic resonance imaging study. Neuroscience 152: 29-39.
  13. DYKES R, MIQUEE A, XERRI C, ZENNOU-AZOGUI Y, RAINVILLE C, DUMOULIN A, MARINEAU D (2007) A Delivery device for presentation of tactile stimuli during functional magnetic resonance imaging. Neurosci. Methods 159: 308-317.
  14. ROSSELET C, ZENNOU-AZOGUI Y, XERRI C (2006). Nursing-induced somatosensory cortex plasticity: Temporally decoupled changes in neuronal receptive field properties are accompanied by modifications in activity-dependent protein expression. Neurosci. 26:10667–10676.
  15. XERRI C, BOURGEON S, COQ JO (2005) Perceptual context-dependent remodeling of the forepaw map in the SI cortex of rats trained on tactile discrimination. Brain Res. 162/2: 207-221.
  16. BOURGEON S, XERRI C, COQ JO (2004) Abilities in tactile discrimination of textures in adult rats exposed to enriched or impoverished environments. Brain Res. 153: 217-231.
  17. XERRI C, ZENNOU-AZOGUI Y (2003). Influence of the postlesion environment and chronic piracetam treatment on the organization of the somatotopic map in the primary somatosensory cortex after focal cortical injury. Neuroscience 118: 161-177 .
  18. COQ J-O, XERRI C (2001) Sensorimotor experience modulates age-dependent alterations of the forepaw representation in the rat primary somatosensory cortex. Neuroscience 104: 705-715
  19. COQ J-O, XERRI C (2000) Age dependent alterations of the cutaneous forepaw representation in the rat primary somatosensory cortex. Neuroscience 99: 403-411.
  20. COQ, J-O., XERRI, C. (1999) Tactile impoverishment and sensory-motor restriction deteriorate the forepaw cutaneous map in the primary somatosensory cortex of adult rats. Brain Res., 129: 518-531.
  21. COQ, J-O., XERRI, C. (1999) Acute reorganization of the forepaw representation in the rat SI cortex after focal cortical injury – neuroprotective effects of piracetam treatment. European J. Neurosci., 11 : 2597-2608.
  22. XERRI, C., MERZENICH, M.M., JENKINS, W.M., SANTUCCI, S. (1999) Representational plasticity in cortical area 3b paralleling tactual-motor skill acquisition in adult monkeys. Cerebral Cortex, 9 : 264-276.
  23. XERRI, C., MERZENICH, M.M., PETERSON, B.E., JENKINS, W.M. (1998) Plasticity of primary somatosensory cortex paralleling sensorimotor skill recovery from stroke in adult monkeys. J. Neurophysiol., 79: 2119-2148.
  24. COQ, J-O., XERRI, C. (1998) Environmental enrichment alters organizational features of the forepaw representation in the primary somatosensory cortex of adult rats. Brain Res., 121: 191-204.
  25. ZENNOU-AZOGUI, Y., XERRI, C., HARLAY, F. (1994) Visual sensory substitution in vestibular compensation: neuronal substrates in the alert cat. Brain Res., 98: 457-473.
  26. XERRI, C., STERN, J., MERZENICH, M.M. (1994) Alterations of the cortical representation of the rat ventrum induced by nursing behavior Neuroscience, 14 (3):1710-1721.
  27. XERRI, C., BOREL, L., BARTHELEMY, J., LACOUR, M. (1988) Neuronal coding of linear motion in the vestibular nuclei of the alert cat. III. Dynamic characteristics of visual-otolith interactions. Brain Res., 70, 299-309.
  28. BARTHELEMY, J., XERRI, C., BOREL, L., LACOUR, M. (1988) Neuronal coding of linear motion in the vestibular nuclei of the alert cat. II. Responses characteristics to vertical optokinetic stimulation. Brain Res., 70, 287-298.
  29. XERRI, C., BARTHELEMY, J., HARLAY, F., BOREL, L., LACOUR, M. (1987) Neuronal coding of linear motion in the vestibular nuclei of the alert cat. I. Response characteristics to vertical otolith stimulation. Exp. Brain Res., 65, 569-581.
  30. XERRI, C., GIANNI, S., MANZONI, D., POMPEIANO, O. (1985) Central compensation of vestibular deficits. IV. Response characteristics of lateral vestibular neurons to neck rotation after labyrinth deafferentation. Neurophysiol., 54,1006-1025.
  31. LACOUR, M., MANZONI, D., POMPEIANO, O., XERRI, C. (1985) Central compensation of vestibular deficits. III. Response characteristics of lateral vestibular neurons to roll tilt after contralateral labyrinth deafferentation. Neurophysiol., 54, 988-1005.
  32. POMPEIANO, O., XERRI, C., GIANNI, S., MANZONI, D. (1984) Central compensation of vestibular deficits. II. Influences of roll tilt on different size lateral vestibular neurons after ipsilateral labyrinth deafferentation. Neurophysiol., 52, 18-38.
  33. XERRI, C., GIANNI, S., MANZONI, D., POMPEIANO, O. (1983) Central compensation of vestibular deficits. I. Response characteristics of lateral vestibular neurons to roll tilt after ipsilateral labyrinth deafferentation. Neurophysiol., 50: 428-448.
  34. LACOUR, M., XERRI, C. (1980) Compensation of postural reactions to fall in the vestibular neurectomized monkey. Role of the visual motion cues. Brain Res., 40, 103-110.
  35. LACOUR, M., XERRI, C., HUGON, M. (1979) Compensation of postural reactions to fall in the vestibular neurectomized monkey. Role of the remaining labyrinthine afferences. Brain Res. 37, 563-580.

Articles de synthèses – Chapitres d’ouvrages

  1. XERRI C (2010) Experience-dependent reorganization of somatosensory and motor cortical areas: towards a neurobiology of rehabilitation. in Brain Mapping: from Neural Basis of Cognition to Surgical Applications. Duffau H (ed). Springer Wien New York. pp 111-129.
  2.  XERRI C (2003) Plasticité des représentations somesthésiques et illusions perceptive : le paradoxe du membre fantôme. Intellectica, 36-37 :67-87.
  3. Merzenich MM, Wright BA, Jenkins W, Xerri C, Byl N, Miller S, Tallal P (2002) Cortical plasticity underlying perceptual, motor, and cognitive skill development: Implications for neurorehabilitation. Johnson, M.H., Munakata, Y. et al. (Eds);” Brain development and cognition: A reader” (2nd ed.). Malden, MA, US: Blackwell Publishers. XIV, pp. 292-304.
  4.  MERZENICH MM, WanG X, XERRI C, Nudo R (1996) Functional plasticity of cortical representations of the hand. In: Somesthesis and the Neurobiology of the Somatosensory Cortex. Franzen, R. Johansson and L. Terenius, (Eds). Birkhäuser:Basel. pp. 249-269.
  5.  MERZENICH MM, Wright B, JENKINS WM, XERRI C, Byl N, Miller S, Tallal S (1996) Cortical plasticity underlying perceptual, motor and cognitive skill development: Implications for Neurorehabilitation. Cold Spring Harbor Symposia on Quantitative Biology, Volume 61, Cold Spring Harbor Press, NY, pp. 1-8.
  6. ZENNOU Y, XERRI C (1992) Vestibular compensation : sensitive period and role of sensory motor activity in substitution process. In : A. Berthoz, W. Graf, P.P. Vidal (Eds). The Head-neck Sensory Motor System. Oxford University Press, pp 617-629.
  7. XERRI C, ZENNOU Y (1989) Sensory, functional and behavioral substitution processes in the vestibular compensation. In Lacour, M., M. Toupet, P. Denise (Eds.). Vestibular compensation: facts, theories and clinical perspectives Elsevier, Paris, pp.35-58